>Thanks for your question. We have not studied any rats other than the Sprague Dawley rats. However, Dr. Boegehold has demonstrated that acetylcholine induced relaxation is impaired in Dahl R rats on a high salt diet. This implies that the effects of high salt diet are not strain dependent.
Bob and Julian,
I would agree that the effect of high dietary salt intake is not strain dependent. We have also seen a salt-dependent suppression of the arteriolar response to ACh in Sprague-Dawley rats, as you have reported, Julian. Also, in normotensive WKY rats, we have seen that 4 weeks of high salt intake leads to a suppression of NO's normal attenuating effect on myogenic constriction (at least in the most proximal arterioles).