Hypertension II: Hypertension and Vascular Control

Re: Dr. J. Lombard (0532) Impaired relaxation of arterioles

Julian H. Lombard

On Thu Dec 10, Robert M.K.W. Lee wrote
>Your observation about high salt diet effect on the functional alterations of arterioles and resistance arteries in normal rats, is interesting.  Have you seen this type of change in other normotensive rats, such as Wistar rats?


Thanks for your question.  We have not studied any rats other than the Sprague Dawley rats.  However, Dr. Boegehold has demonstrated that acetylcholine induced relaxation is impaired in Dahl R rats on a high salt diet.  This implies that the effects of high salt diet are not strain dependent.  

[ This message was edited on Fri Dec 11 by the author ]

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