SERCA-Type of Calcium Pumps and Phospholamban

Re: Poster 338

lompre anne-marie

On Sun Dec 6, grover wrote
>Dr. Lompre:
>  Very interesting results.  Did you examine the effects of agents such as angiotensin or endothelin or the effects of IP3?  Also, what happens to SERCA2b in these cells?

we  used angiotensin to stimulate the IP3 cascade and got the same results than with ATP after 2 days in culture but in freshly isolated cells angiotensin was inactive probably because the receptor was altered by the dissociation.
SERCA 2b was unaltered during culture.

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