SERCA-Type of Calcium Pumps and Phospholamban

Presentation 580


 Thanx for the response. I have considered the PMCA pumps more for cell survival and SERCA pumps more for signal transduction (Grover 1985, Cell Calcium). What do you think of that idea?

On Thu Dec 10, grover wrote
>  You indicate in your poster that some cells express both SERCA2 and SERCA3 and also that the two pumps have different affinities for Ca2+. How do you think the two obsrvations relate in terms of cellular functions?  Do you think that when the two pumps are involved, they are localized in different subcellular compartments?  Do you think co-localization of SERCA2 with phospholamban in that cell would be expeted?  Do you think that there are area in the cell which will be more suceptible to oxidative stress and hence SERCA3 would be more advantageous there?  What do you see the functional advantages of a cell expressing both the isoforms?

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