SERCA-Type of Calcium Pumps and Phospholamban


Presentation 580

grover
groverak@fhs.mcmaster.ca


Frank:
�You indicate in your poster that some cells express both SERCA2 and SERCA3 and also that the two pumps have different affinities for Ca2+. How do you think the two obsrvations relate in terms of cellular functions? �Do you think that when the two pumps are involved, they are localized in different subcellular compartments? �Do you think co-localization of SERCA2 with phospholamban in that cell would be expeted? �Do you think that there are area in the cell which will be more suceptible to oxidative stress and hence SERCA3 would be more advantageous there? �What do you see the functional advantages of a cell expressing both the isoforms?
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