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Invited Symposium: What Can Genetic Models Tell Us About Attention-Deficit Hyperactivity Disorder (ADHD)?






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
Board

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A Behavioral Validation of the Spontaneously Hypertensive Rat (SHR) as an Animal Model of Attention-Deficit/Hyperactivity Disorder (AD/HD)


Contact Person: Terje Sagvolden (terje.sagvolden@basalmed.uio.no)


References

1. Taylor E. (1998) Clinical foundations of hyperactivity research. Behavioural Brain Research, 94, 11-24.

2. Puumala T, Routsalainen S, Jakala P, Koivisto E, Riekkinen P, Jr., Sirviö J. (1996) Behavioral and pharmacological studies on the validation of a new animal model for attention deficit hyperactivity disorder. Neurobiology of Learning and Memory, 66, 198-211.

3. Robbins TW, Jones GH, Sahakian BJ. (1989) Central stimulants, transmitters and attentional disorder: A perspective from animal studies. In: Attention deficit disorder: Clinical and basic research (ed. T Sagvolden, T Archer), pp 199-222. Lawrence Erlbaum Associates, Hillsdale, N.J.

4. Silbergeld EK, Goldberg AM. (1974) Lead - induced behavioral dysfunction: an animal model of hyperactivity. Experimental Neurology, 42, 146-157.

5. Holene E, Nafstad I, Skaare JU, Sagvolden T. (1998) Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126. Behavioural Brain Research, 94, 213-224.

6. Holene E, Nafstad I, Skaare JU, Bernhoft A, Engen P, Sagvolden T. (1995) Behavioral effects of pre- and postnatal exposure to individual polychlorinated biphenyl congeners in rats. Environmental Toxicology and Chemistry, 14, 967-976.

7. Dell'Anna ME, Luthman J, Lindqvist E, Olson L. (1993) Development of monoamine systems after neonatal anoxia in rats. Brain Research Bulletin, 32, 159-170.

8. Diaz-Granados JL, Greene PL, Amsel A. (1994) Selective activity enhancement and persistence in weanling rats after hippocampal X-irradiation in infancy: possible relevance for ADHD. Behavioral and Neural Biology, 61, 251-259.

9. Archer T. (1989) Neurotoxin-induced cognitive and motor activity modifications: A catecholamine connection. In: Attention deficit disorder: Clinical and basic research (ed. T Sagvolden, T Archer), pp 287-322. Lawrence Erlbaum Associates, Hillsdale, N.J.

10. Shaywitz BA, Yager RD, Klopper JH. (1976) Selective brain dopamine depletion in developing rats: an experimental model of minimal brain dysfunction. Science, 191, 305-308.

11. Shaywitz BA, Klopper JH, Yager RD, Gordon JW. (1976) Paradoxical response to amphetamine in developing rats treated with 6-hydroxydopamine. Nature, 261, 153-155.

12. Berger DF, Sagvolden T. (1998) Sex differences in operant discrimination behaviour in an animal model of Attention-Deficit Hyperactivity Disorder. Behavioural Brain Research, 94, 73-82.

13. Boix F, Qiao S-W, Kolpus T, Sagvolden T. (1998) Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder. Behavioural Brain Research, 94, 153-162.

14. Knardahl S, Sagvolden T. (1979) Open-field behavior of spontaneously hypertensive rats. Behavioral and Neural Biology, 27, 187-200.

15. McCarty R, Kopin IJ. (1979) Patterns of behavioral development in spontaneously hypertensive rats and Wistar-Kyoto normotensive controls. Developmental Psychobiology, 12, 239-243.

16. Mook DM, Jeffrey J, Neuringer A. (1993) Spontaneously hypertensive rats (SHR) readily learn to vary but not repeat instrumental responses. Behavioral and Neural Biology, 59, 126-135.

17. Moser M-B, Moser EI, Wultz B, Sagvolden T. (1988) Component analyses differentiate between exploratory behaviour of spontaneously hypertensive rats and Wistar Kyoto rats in a two- compartment free-exploration open field. Scandinavian Journal of Psychology, 29, 200-206.

18. Myers MM, Musty RE, Hendley ED. (1982) Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine. Behavioral and Neural Biology, 34, 42-54.

19. Sagvolden T, Hendley ED, Knardahl S. (1992) Behavior of hypertensive and hyperactive rat strains: Hyperactivity is not unitarily determined. Physiology and Behavior, 52, 49-57.

20. Sagvolden T, Metzger MA, Schiørbeck HK, Rugland AL, Spinnangr I, Sagvolden G. (1992) The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants. Behavioral and Neural Biology, 58, 103-112.

21. Sagvolden T, Pettersen MB, Larsen MC. (1993) Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains. Physiology and Behavior, 54, 1047-1055.

22. Wultz B, Sagvolden T. (1992) The hyperactive spontaneously hypertensive rat learns to sit still, but not to stop bursts of responses with short interresponse times. Behavior Genetics, 22, 415-433.

23. Wultz B, Sagvolden T, Moser EI, Moser M-B. (1990) The spontaneously hypertensive rat as an animal model of attention-deficit hyperactivity disorder: effects of methylphenidate on exploratory behavior. Behavioral and Neural Biology, 53, 88-102.

24. Sadile AG, Pellicano MP, Sagvolden T, Sergeant JA. (1996) NMDA and non-NMDA sensitive [L-3H] glutamate receptor binding in the brain of the Naples high- and low-excitability rats: An autoradiographic study. Behavioural Brain Research, 78, 163-174.

25. Sadile AG. (1993) What can genetic models tell us about behavioral plasticity? Reviews in the Neurosciences, 4, 287-303.

26. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. (1996) Hyperlocomotion and indifference to cocaine amphetamine in mice lacking the dopamine transporter. Nature, 379, 606-612.

27. Okamoto K, Aoki K. (1963) Development of a strain of spontaneously hypertensive rats. Japanese Circulation Journal, 27, 282-293.

28. Hendley, E. D. Development of WKHA inbred rat strain with genetic hyperactivity and hyperreactivity to stress. 1998. Internet Communication.

29. Hendley ED, Wessel DJ, Van Houten J. (1986) Inbreeding of Wistar-Kyoto rat strain with hyperactivity but without hypertension. Behavioral and Neural Biology, 45, 1-16.

30. McKinney WT, Bunney WE. (1969) Animal model of depression. Archives of General Psychiatry, 21, 240-248.

31. Sarter M, Hagan J, Dudchenko P. (1992) Behavioral screening for cognition enhancers: From indiscriminate to valid testing: Part I. Psychopharmacology, 107, 144-159.

32. Willner P. (1984) The validity of animal models of depression. Psychopharmacology, 83, 1-16.

33. Willner P. (1986) Validation criteria for animal models of human mental disorders: Learned helplessness as a paradigm case. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 10, 677-690.

34. Sagvolden T, Aase H, Zeiner P, Berger DF. (1998) Altered reinforcement mechanisms in Attention-Deficit Hyperactivity Disorder. Behavioural Brain Research, 94, 61-71.

35. Sergeant JA, van der Meere JJ. (1990) Convergence of approaches in localizing the hyperactivity deficit. In: ed. BB Lahey, AE Kazdin), pp 207-245.

36. Sergeant JA, Scholten CA. (1985) On data limitations on hyperactivity. Journal of Child Psychology and Psychiatry, 26, 111-124.

37. Douglas VI. (1983) Attentional and cognitive problems. In: Developmental Neuropsychiatry (ed. M Rutter), pp 280-329. Guilford Press, New York.

38. van der Meere JJ. (1996) The role of attention. In: Monographs in child and adolescent psychiatry. Hyperactivity disorders of childhood (ed. ST Sandberg), pp 109-146. Cambridge University Press, Cambridge.

39. Porrino LJ, Rapoport JL, Behar D, Sceery W, Ismond DR, Bunney WE. (1983) A naturalistic assessment of the motor activity of hyperactive boys. I. Comparison with normal controls. Archives of General Psychiatry, 40, 681-687.

40. Sleator EK, Ullman RK. (1981) Can a physician diagnose hyperactivity in the office? Pediatrics, 67, 13-17.

41. Sagvolden T, Sergeant JA. (1998) Attention Deficit/Hyperactivity Disorder - From brain dysfunctions to behaviour. Behavioural Brain Research, 94, 1-10.

42. Evenden, J. L. Serotonergic and Steroidal Influences on Impulsive Behaviour in Rats. 1998. University of Uppsala. Thesis/Dissertation.

43. Oosterlaan J, Sergeant JA. (1998) Response inhibition and response re-engagement in ADHD, disruptive, anxious and normal children. Behavioural Brain Research, 94, 33-43.

44. Rubia K, Oosterlaan J, Sergeant JA, Brandeis D, van Leeuwen T. (1998) Inhibitory dysfunction in hyperactive boys. Behavioural Brain Research, 94, 25-32.

45. Sagvolden T, Metzger MA, Sagvolden G. (1993) Frequent reward eliminates differences in activity between hyperkinetic rats and controls. Behavioral and Neural Biology, 59, 225-229.

46. Cook EH, Jr., Stein MA, Krasowski MD, et al. (1995) Association of attention-deficit disorder and the dopamine transporter gene. American Journal of Human Genetics, 56, 993-998.

47. LaHoste GJ, Swanson JM, Wigal SB, et al. (1996) Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Molecular Psychiatry, 1, 121-124.

48. Swanson, J. M. Dopamine genes and ADHD. 1998. Internet Communication.

49. Carey MP, Diewald LM, Esposito F, et al. (1998) Differential distribution, affinity and plasticity of dopamine D-1 and D-2 receptors in the target sites of the mesolimbic system in an animal model of ADHD. Behavioural Brain Research, 94, 173-185.

50. Linthorst ACE, De Lang H, De Jong W, Versteeg DH. (1991) Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats. European Journal of Pharmacology, 201, 125-133.

51. Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J. (1998) Differences between electrically-, ritalin- and D-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of Attention-Deficit Hyperactivity Disorder. Behavioural Brain Research, 94, 163-171.

52. Russell, V. A. The nucleus accumbens motor-limbic interface of the Spontaneously Hypertensive Rat (SHR) as studied In-Vitro by the superfusion slice technique. 1998. Internet Communication.

53. Sadile, A. G. and Papa, M. Segmental defect in the anterior forebrain of an animal model of ADHD: Long lasting network consequences revealed by molecular imaging probes. 1998. Internet Communication.

54. Di Chiara, G. The nucleus accumbens and its integrative role as interface between limbic-motor circuitries. 1998. Internet Communication.

55. Douglas VI, Parry PA. (1994) Effects of reward and nonreward on frustration and attention in attention deficit disorder. Journal of Abnormal Child Psychology, 22, 281-301.

56. Sagvolden T. (1996) The attention deficit disorder might be a reinforcement deficit disorder. In: Contemporary Psychology in Europe: Theory, Research, and Application (ed. J Georgas, M Manthouli, E Besevegis, A Kokkevi), pp 131-143. Hogrefe and Huber, Göttingen.

57. Sagvolden T, Archer T. (1989) Future perspectives on ADD research -- An irresistible challenge. In: Attention deficit disorder: Clinical and basic research (ed. T Sagvolden, T Archer), pp 369-389. Lawrence Erlbaum Associates, Hillsdale, N.J.

58. Sonuga-Barke EJS, Taylor E, Sembi S, Smith J. (1992) Hyperactivity and delay aversion I: the effect of delay on choice. Journal of Child Psychology and Psychiatry, 33, 387-398.

59. Wender PH. (1971) Minimal brain dysfunction in children. Wiley, New York.

60. Catania AC, Sagvolden T, Keller KJ. (1988) Reinforcement schedules: Retroactive and proactive effects of reinforcers inserted into fixed-interval performance. Journal of the Experimental Analysis of Behavior, 49, 49-73.

61. Catania AC. (1971) Reinforcement schedules: The role of responses preceding the one that produces the reinforcer. Journal of the Experimental Analysis of Behavior, 15, 271-287.

62. Saldana RL, Neuringer A. (1998) Is instrumental variability abnormally high in children exhibiting ADHD and aggressive behavior? Behavioural Brain Research, 94, 51-59.

63. Catania AC, Sagvolden T, Aase H. (1997) Delay of Reinforcement and the Hyperactivity Syndrome. Society for the Quantitative Analysis of Behavior, 8.

64. Papa M, Berger DF, Sagvolden T, Sergeant JA, Sadile AG. (1998) A quantitative cytochrome oxidase mapping study, cross-regional and neurobehavioural correlations in the anterior forebrain of an animal model of Attention Deficit Hyperactivity Disorder. Behavioural Brain Research, 94, 197-211.

65. Solanto-Gardner, M. V. Clinical psychopharmacology of ADHD: Implications for animal models. 1998. Conference Proceeding.

66. Solanto MV. (1998) Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration. Behavioural Brain Research, 94, 127-152.

67. de Villiers AS, Russell VA, Sagvolden T, Searson A, Jaffer A, Taljaard JJF. (1995) alpha2-Adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for Attention Deficit Hyperactivity Disorder. Neurochemical Research, 20, 357-363.

68. Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J. (1995) Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of Attention- Deficit Hyperactivity Disorder - the spontaneously hypertensive rat. Brain Research, 676, 343-351.

69. Sagvolden T, Slåtta K, Arntzen E. (1988) Low doses of methylphenidate (Ritalin) may alter the delay-of- reinforcement gradient. Psychopharmacology (Berlin), 95, 303-312.

70. Krimer LS, Muly C, Williams GV, Goldman-Rakic PS. (1998) Dopaminergic regulation of cerebral cortical microcirculation. Nature Neuroscience, 1, 286-289.

71. Thyrum ET, Blumenthal JA, Madden DJ, Siegel W. (1995) Family history of hypertension influences neurobehavioral function in hypertensive patients. Psychosomatic Medicine, 57, 496-500.

72. Stinus L, Cador M, Le Moal M. (1992) Interaction between endogenous opioids and dopamine within the nucleus accumbens. Annals of the New York Academy of Sciences, 654, 254-273.

73. Robbins TW, Granon S, Muir JL, Durantou F, Harrison A, Everitt BJ. (1998) Neural systems underlying arousal and attention. Implications for drug abuse. Annals of the New York Academy of Sciences, 846, 222-237.

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<= Discussion & Conclussions REFERENCES

| Discussion Board | Next Page | Your Symposium |
Sagvolden, T.; (1998). A Behavioral Validation of the Spontaneously Hypertensive Rat (SHR) as an Animal Model of Attention-Deficit/Hyperactivity Disorder (AD/HD). Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/sadile/sagvolden0567/index.html
© 1998 Author(s) Hold Copyright