Pharmacology & Toxicology Poster Session
Discussion and Conclusion
Vanadate mediates a tyrosine kinase dependent enhancement of adenylyl cyclase isoform VI activity; further, this is related to a tyrosine kinase-dependent serine phosphorylation of the catalytic subunit. Mutation of serine residues located in and adjacent to the C1b catalytic region completely abrogates the vanadate-mediated enhancement of adenylyl cyclase activity. Tyrosine kinase-dependent serine phosphorylation represents a novel mechanism whereby tyrosine kinase activation may modify G-protein linked responses.
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|Tan, CM; Feldman, RD; (1998). Tyrosine Kinase-Mediated Serine Phosphorylation and Enhancement of Adenylyl Cyclase Activity. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/pharmtox/tan0766/index.html|
|© 1998 Author(s) Hold Copyright|