Neuropharmacology Poster Session
Karbovski, E. (Beer Sheva Mental Health Center, Beer Sheva, Israel)
Belmaker, RH. (Division of Psychiatry, Ben Gurion University of the Negev, Israel)
Inositol is a natural isomer of glucose that is the precursor in the phosphatidylinositol (PIP) cycle, a source of two second messengers: diacylglycerol (DAG) and inositol triphosphate (IP3). Reports from clinical studies indicate that inositol can be effective in relieving symptoms of depression in patients. To permit the study of the mechanism of this effect animal research may be necessary. The present study examined the effects of inositol on two animal models of depression: the Porsolt forced swim test, a behaviorally based model; and the reserpine induced immobility model, a pharmacologically based model. Chronic inositol injections (daily, for 14 days) 1.2 gm/kg but not in lower doses, reduced immobility time and increased struggle time in the Porsolt test compared with control animals. The same dose and treatment schedule also reduced 'complete immobility time' but did not affect ambulatory activity in the reserpine test compared with controls. Chronic oral treatment with inositol (10% in food for 14 days) had similar effects to injections in the Porsolt test. The effects of inositol in animal models of depression support its possible importance as a new treatment for the disorder, and permit research on its mechanisms of action.
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|Einat, H.; Karbovski, E.; Belmaker, RH.; (1998). Reduced Depressive-like Behaviors in Animal Models of Depression Following Chronic Inositol Treatment. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/einat0317/index.html|
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