Jeffrey T. Henderson, Mohammed Javaheri, Susan Kopko and John C. Roder
Samuel Lunenfeld Research Institute, Mount Sinai
Program in Molecular Biology and Cancer, 600 University Ave., Toronto, Ontario M5G-1X5
Figure 6.Levels of glutathione peroxidase activity in cervical spinal cord segments of
NW, wr/wr and wr/wr(N) animals.
Figure 6.Levels of glutathione peroxidase activity in cervical spinal cord segments of NW, wr/wr and wr/wr(N) animals.
NAC treatment augments glutathione peroxidase (GPx) levels in the cervical spinal cord of wobbler mice.
Spinal cord (C3-C7) segments were dissected and assayed for GPx activity in 9-week-old wobbler mice.
GPx values are plotted as a percentage of the NW group. The NW(N+) group represents a positive control, consisting of NW
animals (glucose supplimented) given daily i.p. injections of N-acetyl-L-cysteine (1 mg/gram/day) for three days
prior to sacrifice. For NW and NW(N) groups, n=4; for wr/wr and wr/wr(N) groups, n=6. Values represent the mean + SEM;
asterisks indicate p<0.05 for a given group, versus the wr/wr group. For wr/wr vs. wr/wr(N), p<0.03; for wr/wr vs. NW or NW(N), p<0.01.