Congratulations on your excellent work! You have provided strong evidence indicating that rotundine significantly inhibits the development of morphine tolerance. From my point of view, the most important significance obtained from your work is the novel idea that compounds isolated from Chinese medicinal herbs are effective in inhibiting morphine tolerance and dependence. This is an exciting finding since Chinese medicinal herbs are great resourceful, in which more and better compounds should be found to treat clinically the patients with morphine tolerance. Certainly, Chinese medicine would make greater contributions to the whole human race and the world medicine.
Dr. Hui Dong