Thanks for the comment and yes I am enjoying the meeting. You are right, the northern blot data would suggest that GRK-2 mRNA is not the answer for the increase in GRK-2 protein expression. Altered protein stability in a strong possibility as a potential explanation for the increase in GRK-2 protein expression in both human and rat lymphocytes and rat vascular tissues.
Thanks for your comments,
On Sun Dec 6, Grover wrote
>"Dr. Gros: I am glad to see your nice presentation and hope you enjoy the meeting. You conclude that the increased GRK-2 protein content in hypertension is not due to an increase in GRK-2 messenger RNA. Do you think then the mechanism involves a difference in protein stability or translation?"