Pharmacology & Toxicology
Dr. Bou: Great presentation. Hope you have fun at the meeting. You conclude that Tg8 mutant mice obtained from C3H mice by disrupting the gene encoding monoamine oxidase-A - the serotonin (5-HT) degradation enzyme - showed very high 5-HT levels at birth and that is how the respiration rate in these rats was abnormal. How selective is monoamine oxidase A for serotonin? I understood that it was not very selective and if so how uniquely can you interpret your results?
Sun Dec 6