Oxidative Stress and the CNS

Symposium 216


Dr. Juurlink:  Hope you are enjoying the meeting.  Great poster.  You indicate that "increases in tissue GSH can be accomplished either by administering compounds that increase intracellular levels of the rate-limiting amino acid, cysteine, for GSH synthesis or by promoting the activity of the rate-limiting enzyme, glutamyl-cysteine synthase."  What is the evidence that this enzyme is rate limiting vs. that the energy metabolism favors GSSG rather than GSH?

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