Oxidative Stress and the
Dr. Yim: Great presentation. Hope you have fun at the meeting. You conclude: H2O2 [wild-type (44 mM) > G93A (25 mM)> A4V (13 mM)]. An apparent correlation between the Km values for H2O2 and the clinical severity of the disease for the two FALS mutants suggest that free radical may play a role in the progression of ALS. I have a problem with this explanation because the Km values for peroxide are too high for the amounts of peroxide that could ever be accumulated. Is there a difference in the turnover rates in these mutants that happens to correlate with the Km?
Sun Dec 6