Oxidative Stress and the CNS

Symposium 183


Dr. Yim:  Great presentation.  Hope you have fun at the meeting. You conclude: H2O2 [wild-type (44 mM) > G93A (25 mM)> A4V (13 mM)]. An apparent correlation between the Km values for H2O2 and the clinical severity of the disease for the two FALS mutants suggest that free radical may play a role in the progression of ALS.  I have a problem with this explanation because the Km values for peroxide are too high for the amounts of peroxide that could ever be accumulated.  Is there a difference in the turnover rates in these mutants that happens to correlate with the Km?

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