Oxidative Stress and the CNS

Symposium 139

Dr. Schipper: Hope you are enjoying the meeting. �Great poster. If I am to understand the model correctly - it is based on a free radical mediated damage inducing hemoxygenase, followed by mitochondrial damage which leads to deposition of iron in mitochondria of astroglia. �Three questions. �First in what is the evidence that in Parkinson disesase, a mitochondrial damage preceeds hemoxygenase induction and iron deposition in astroglia? �Second, how do you propose this model to produce a neuronal damage - simply as an ability of astroglia to protect and/or communicate with the neurons? �Third, what would make this damage specific only to certain regions of the brain?

Sun Dec 6