Oxidative Stress and the
Dr. Schipper: Hope you are enjoying the meeting. Great poster. If I am to understand the model correctly - it is based on a free radical mediated damage inducing hemoxygenase, followed by mitochondrial damage which leads to deposition of iron in mitochondria of astroglia. Three questions. First in what is the evidence that in Parkinson disesase, a mitochondrial damage preceeds hemoxygenase induction and iron deposition in astroglia? Second, how do you propose this model to produce a neuronal damage - simply as an ability of astroglia to protect and/or communicate with the neurons? Third, what would make this damage specific only to certain regions of the brain?
Sun Dec 6