Oxidative Stress and the CNS

Re^4: Symposium 783

Bernhard H.J. Juurlink

Thanks,  You are probably right in that there is no need to have an ascorbate metabolic coupling between neurons and astrocytes.  There is much evidence that astrocytes send reducing equivalents to neurons in the form of lactate (note the research of B. Hamprecht and R. Dringen).  The lactate in neurons would be converted to pyruvate with NAD being reduced to NADH: transhydrogenases can enable NADP to be reduced to NADPH with NADH being oxidized to NAD.  NADPH would then enable reduction of the GSSG (via glutathione reductase) formed because of reduction of oxidized ascorbate.  

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