Glaucoma: Diagnosis and Therapy

Re: Unoprostone Eye Drops

Kazuo Emi

On Wed Dec 9, Janos Nemeth M.D. wrote
>To Dr. Kazuo Emi

>Thank you very much for your presentation. My question is: Did you find any correlation between the individual intraocular pressure lowering effect of Unoprostone eye drop and the amount of blood flow velocity increase. Do you think that the longterm effect of Unoprostone on blood flow circulation might be the same as the acute effect?
>Janos Nemeth M.D.

Reply to Dr. Nemeth

Thank you for the very interesting question. I guess you want to
ask whether the increment of the velocity in the orbital vessels
depends on the pressure gradient between the blood pressure
and the intraocular pressure or not in the first question.
Unfortunately I have no statistical data of that. I think its very
important point whether the change of the velocity only depends
on the pressure gradient or not. For your second question, I have
the results of betaxolol for POAG which indicate the resistive
index decreases only in the long-term( one year) use. I guess it
may be an accumulation effect of betaxolol. We have only the
short-term results in normal-tension glaucomas that the resistive
index was decreased only in the PCA and the peak-systolic
velocity and end-diastolic velocity had the tendacy to increase in
both CRA and PCA. As for the long-term behavior of the
unoprostone, we just started the long-term study for normal-
tension glaucomas.

Kazuo Emi MD

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