Glaucoma: Diagnosis and Therapy

Re^2: Symposium 244


Dr. Budde:
Does this mean that leakage if it occurs is at a more advanced stage of the disease?

On Fri Dec 11, Wido M Budde wrote

>Dear Dr. Grover,
>Right now we are not very sure about the possibility of a leakage of vasoactive substances as an important pathogenetic factor in the development of glaucomatous optic nerve fiber loss and enlargement of parapapillary atrophy. Reason against the leakage is the finding in fluorescein angiography, where no leakage of  fluorescein into the vitreous or subretinal space can be observed in glaucomatous eye with parapapillary atrophy.

>Wido Budde
>On Sun Dec 6, Grover wrote
>>Dr. Budde: Great presentation.  Hope you have fun at the meeting.You indicate that parapapillary atrophy with possible leakage of vasoactive substances from the choriocapillaris into the retina has been discussed to be important for the development of glaucomatous optic nerve fiber loss in eyes with normal intraocular pressure.  It is not clear to me whether this suggests that the leakage of vasoactive substances the etiology of this atrophy or a consequence.


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