Glaucoma: Diagnosis and Therapy

Re: Ultrasound Contrast Agent by Pavlin et al

c pavlin

On Tue Dec 15, Janos Nemeth M.D. wrote
>to Charles Pavlin M.D.

>Thank you for the very interesting experimental study. My questions are: Is it possible to image the ulrasound contrast material using conventional 10 MHz B-scan in cadaver eyes?
>What is your opinion about the use of US contrast agent in a living eye? I think in a normal eye the contrast material does not enter into the eyeball, but we might image the circulation of small orbital and intraocular vessels better. In pathological cases we might study the pathologic vessels like the inside vasculature of a tumor. Do you have experience in this field? What about other applications?  

>Janos Nemeth M.D.
Dear Janos
The ultrasound contrast material is imaged very clearly with conventional ultrasound, and this formed an important part of our study.
- Injection into the eye in clinical situations would be of concern regarding glaucoma caused by slow contrast clearance.  The bubbles could be blown up to clear them however.
- Contrast injected into the vascular system definitely enhances the Doppler signal.  This has been proven elsewhere in the body, but to date we have not assessed its use in living eyes.

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