Molecular and Cellular Analysis of Dopamine and Serotonin Transporters

Dr. Kuhar

Rabi Simantov

Could you (or other participants in this symposium) speculate more about the implications of this exciting finding, that DAT and possibly other plasma membrane transporters are located more perisynaptically than intrasynaptically?
For example, if diffusion if much more important than originally assumed, can this influence the design of antidepressive drugs? Similarly, can this change the approaches to block psychostimulants such as cocaine, amphetamine, or even MDMA?
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