Molecular and Cellular Analysis of Dopamine and Serotonin Transporters

Re: Presentation 780

Z. B. Pristupa

Dr. Grover,

To date we have looked at DAT distribution changes mediated by MAP2c, D2 receptors (Presentation 786), and manipulation of the protein kinase C system (Pristupa et al. 1998) in heterologous expression systems only. We speculate that similar membrane <-> intracellular redistribution would be observed in native dopaminergic neurons, although this has not yet been investigated. Distribution changes between perisynaptic and synaptic regions would certainly be an additional potential mechanism for the regulation of dopamine transport and neurotransmission.

Thank you for the comment and insightful question.

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