Pineal and its Hormone Melatonin

Direct or indirect effects on the retinal-pineal pathway including the SCN


Dear Dave,

Indeed, there is good evidence that the phase shifting responses must involve the SCN. I am also in accord with your interpretation that it is highly possible that the SCN is the site of action. However, may be you would agree that one still cannot rule out the possibility of an indirect action on other neural substrates that modulate the SCN activities. Regards


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