Neural Substrates of Sexual Motivation and Performance as Revealed by Neural Immediate-Early Gene Expression

Re: Influences of Mating Stimulation on Sex Steroid, Receptor-containing Neurons: Use of Immediate Early Proteins

Jeff Blaustein

We know a lot of pieces that relate to the question, but cannot answer the innervation and DA-mediated activation question directly.

We know that there is tyrosine hydroxylase innervation of PR-containing neurons, at least in guinea pigs (i.e., "nonconventional junctional complexes; TJ Brown et al., 1990), and we know that there are TH-ir varicosities associated with PR-IR cells from our own work.  We also know that there is vaginocervical stimulation induced DARPP-32 phosphorylation in cells in many of these areas, and that at least some of these neurons contain PRs.  We do not yet have the answer to the question of colocalization of dopamine receptors on PR-ir neurons.

On Sat Dec 12, michael baum wrote
>What is known about the actual dopaminergic innervation of and potential DA-mediated activation of PR containing neurons in response to VCS?

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