What Can Genetic Models Tell Us About Attention-Deficit Hyperactivity Disorder (ADHD)?

0341: relating in vitro studies to functional effects

Henry Szechtman

Hi Vivienne, the question I have is one that often comes to mind when one tries to relate in vitro studies to behavioural effects - how can one show that the DA changes observed in the slice reflect the postulated behavioural dysfunction, here, ADHD?  Why is it "dysfunction" rather than normal function of a compensated system? And why is it related to ADHD and not, for instance, to psychosis, depression, OCD or other DA-implicated disorders?
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