Signal Transduction in Endothelium: Mechano-Sensing, Ion Channels and Intracellular Calcium

Poster0242: B. Nilius

Paul Fransen

Dr. Nilius,
Congratulations with the session and the presentation. In your presentation, you showed that chloride channels play an important role in determining the resting membrane potential and hence may influence Ca-signalling. In our work on endocardial endothelial cells, we also found an important contribution of external chloride in determining Vm, but we also observed an important effect of internal chloride, which suggested that there might be a complex interaction between internal and external chloride in Ca-signalling of endothelial cells (Fransen and Sys, 1997). Do you or does anyone else have an idea about effects of internal chloride on Ca-release as has been demonstrated for monovalent cations (Wood and Gillespie, Cardiovasc. Res. 37: 263-270, 1998).  
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