Stroke/Cerebral Vasospasm


Evidence for VIP and NO as dual neurotransmitters in cerebral arteries

Marilyn J. Cipolla
cipollam@ohsu.edu


This is an important study that demonstrates the global involvement of NO in cerebral arteries, both intraluminally (endothelial) and now �extraluminally (perivascular neuronal). �I have always suspected neuronal NO to be important in these arteries and it has been shown nicely in this study. �Could you tell me how specific is the neuronal NO inhibitor that you used? �Also, basal NO release by cerebral arteries antagonizes the substantial tone in these vessels, as demonstrated by the 30-40% contraction in the presence of L-NNA. �However, this is a rather non-specific NO inhibitor. Do you know the contribution of neuronal vs. endothelial NO to basal NO release in cerebral arteries?
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