Stroke/Cerebral Vasospasm

Oxyhemglobin induced apoptosis

R Loch Macdonald

Dear John

I was interested to know what type of hemoglobin did you use in your endothelial cell studies?  do you have reason to believe that aortic endothelial cells will react the same as cerebral ones?  To be the devil's advocate, it is accepted that endothelial cells die after SAH so does it matter how?  On the other hand, I think I know at least one reason that it might be important - obviously from a scientific perspective but also if it is an active process such as apoptosis then there must be some induced change in gene expression.  So it would be very interesting to know what the changes are and what causes them - certainly from the point of view of vasospasm but also atherosclerosis.

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