Carbon Monoxide and Cardiovascular Function

Endothelium and CO

Rui Wang

Dr. Johnson, I greatly enjoy to see your fine presentation.  The role played by endothelium in the vascular functions of CO has not been clear.  Certainly your work and your view on this issue will have an important impact on our understanding of the integrated vascular effect of CO.

(1)  Since CO can freely across membrane, CO might just be produced in vascular smooth muscle cells and permeat to endothelial cell.  There CO affects NOS system.  What's your view on this modified model?

(2)  What could be the physiological stimuli that selectively activate endothelial HO or smooth muscle HO?  A more generalized question is what can act as the endogenous factor to release CO?

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