Carbon Monoxide and Cardiovascular Function

How about iron?

Rui Wang

Thank you for contributing your important and novel studies to this symposium.  

Heme oxygenase (HO) has been regarded as the indirect antioxidant in the literature for the effects of its products -  billiverdin and billirubin.  However, heme metabolism also generates irons. The latter are strong oxidant.  May the cellular damage induced iron-mediated free radical generation overcome the antioxidant protection offered by billiverdin?

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