Cardiovascular Diseases Poster Session

Genes but no drugs

Craig J Daly
c.daly@bio.gla.ac.uk

I'd be interested to know if pharmacologists and physiologists have found it useful to be given the gene for their receptor of interest often well in advance of the development of a high affinity selective ligand for that receptor.

For alpha1-adrenoceptors we are now forced to think in terms of 3 subtypes (because we have the 3 genes) even though there are few (if any) compounds that can 'cleanly' distinguish the 3 subtypes in FUNCTIONAL assays.

Craig.

[ Previous ] [ Next ] [ Index ]           Fri Dec 4