Hypertension I: Structure of Small Arteries in Hypertension

Re^2: Dr. Hale (0778)

Robert M.K.W. Lee
rmkwlee@fhs.mcmaster.ca

On Thu Dec 10, Taben Hale wrote
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>On Wed Dec 9, Robert M.K.W. Lee wrote
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>>Is your "structurally-based vascular resistance" regression after 2 weeks of treatment a function of the lumen size change?

>Although morphometric analysis has not been performed, I do not believe that there has been any change in the lumen size after two weeks of treatment. This is because maximum dilation occurs at the same perfusion pressure in the treated animals as the untreated. Treated animals however achieve maximum vasoconstriction at a perfusion pressure that is lower than the untreated animals, suggesting a reduction in the bulk of vascular smooth muscle tissue.

Do you have any evidence that there was a reduction in the bulk of vascular smooth muscle tissue? Could the change in the sentivity of the tissue to the agonist account for this?

Thu Dec 10