Hypertension I: Structure of Small Arteries in Hypertension

Re: Dr. Hale (0778)

Taben Hale

On Fri Dec 11, M.J. Mulvany wrote
>Dr. Hale,

>Thank you for your interesting results, which confirm nicely that the structure of the vasculature can change rapidly.  We found, for example, that in rabbit esophageal vein that there was a doubling of material just four days after induction of portal hypertension (Juhl CO, Jensen LS, Mulvany MJ: Time course development of changes in the structure and reactivity of small veins from portal hypertensive rabbits.  Clin Sci 1989,77:205-211.)

>Maybe regression can occur just as quickly?  Incidentally, are you sure that you are observing regression and not failure to develop?

>Michael Mulvany
We are fairly confident that what was observed was not merely failure to develop because we used adult (15 wks old) SHRs.  At this stage in their lives they have a fully established hypertension and their vasculature should be fully developed.  Of course there are age-related changes in the vasculature (and hence blood pressure) but I don't believe that we have just prevented these due to the degree of regression that was observed.  

Taben Hale

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