Cardiac Ischemia Reperfusion

symposium # 723

Adel Elmoselhi

Hi Dr. Lukas, very interesting study. I was just wonder if it is known which isoform of PKC is activated for each G-protein receptors. Since you have shown kind of an opposite functions for different PKC isoforms, with PKC-delta and PKC-mu protect cell injury and decrease arrythmogenesis, while PKC-zeta induces contractile dysfunction during ischemia, so what would be the net result especially in a tissue that has different isoforms, does it depends on their expression or the receptors that activate them or something else. It would be really interesting to understand the mechanism(s).
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