Cardiac Ischemia Reperfusion

symposium # 723

Adel Elmoselhi
elmosel@fhs.csu.mcmaster.ca

Hi Dr. Lukas, very interesting study. I was just wonder if it is known which isoform of PKC is activated for each G-protein receptors. Since you have shown kind of an opposite functions for different PKC isoforms, with PKC-delta and PKC-mu protect cell injury and decrease arrythmogenesis, while PKC-zeta induces contractile dysfunction during ischemia, so what would be the net result especially in a tissue that has different isoforms, does it depends on their expression or the receptors that activate them or something else. It would be really interesting to understand the mechanism(s).

Tue Dec 8