SERCA-Type of Calcium Pumps and Phospholamban

Re^2: For poster 0338 Marie anne lompre

Douglas Mack

On Wed Dec 9, OZOG anne wrote
>On Tue Dec 8, Douglas Mack wrote
>>This is in regards to the fact that you found no SERCA3a in endothelial cells, but state later that it has been found in all tissue studied to date. As well, I believe that coexpression of SERCA3b or 3c with 3a  has been recognised to be common in most tissues. Finally, I had thought that the occurence of SERCA3a in endothelial cells was reported, I may be wrong, though.  Can you comment on this.
>SERCA3b is the only SERCA3 isoform expressed in endothelial cells to date, and it's expressed in all tissues studied. But, in all other tissues we examined SERCA3a is also present. To my knowledge endothelial cells are the only report of just one SERCA3 isoform present. We didn't detect the SERCA3c or another spliced variant.



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