SERCA-Type of Calcium Pumps and Phospholamban

Re: Poster 237

On Sun Dec 6, grover wrote
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>Dr. Chu
> How do the effects of beta adrenergic stimulation compare in PLB null mice, in mice with PLB introduced and the control mice?

Dear Dr. Grover:
1) The PLB null hearts are operating at very high contractile levels and they can only be slightly stimulated by beta-agonists.
2) The mouse hearts with PLB reintroduced can be stimulated by isoproterenol similarly to wild-type controls.
3) The maximally-stimulated contractile parameters in all three groups are similar.

Tue Dec 8