Molecular Physiology of Sodium-Calcium Exchange

Re: Poster 411

Jonathan Lytton

On Sun Dec 6, grover wrote
>Dr. Li: Fascinating result. I am glad to see your nice presentation and hope you enjoy the meeting.  What do you think are the molecular mechanisms which lead to the formation of the circular transcript?
Thanks Grover. Interesting question - I forget now if I left this part out, but we think that it may be the unusually large size of exon 2 which allows its 3' end to be arranged in space close to its own 5' end, instead of to the 5' end of the subsequent exon. As a result, circularization is a frequent splicing event. This may also be related to the fact that the exons after exon 2 are subject to alternative splicing. Perhaps this influences kinetics also? Any ideas are welcome!
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