Molecular Physiology of Sodium-Calcium Exchange

Re: Re (881) Alternative NCX1 splicing

Dan Schulze

On Tue Dec 15, Jonathan Lytton wrote

>Interesting data! Sounds like you are starting to localize the region that seems to be involved in the PKA regulation. Any more info regarding actual phosphorylation of the NCX1 molecule itself? Maybe we need one of those AKAP clones to get it to go?
Jonathan, you may be right about the AKAPs being required.  It has been very difficult getting the phophorylated protein.  We have begun making the site directed mutations in the a exon that could be responsible but have not expressed them yet.

[ Previous ] [ Next ] [ Index ]           Wed Dec 16