Molecular Mechanisms of Ageing

To Dr. Chung MH

Masayuki Mori

I agree to your idea that Ogg1 might be involved in biological phenomena, such as aging or carcinogenesis through its repair activity.  It is well known that male germ cells have a lower spontaneous mutation frequency than somatic tissues in mice.  Mice may have higher activity of DNA repair enzymes including the Ogg1 in testes.  I would like to know if you have measured Ogg1 activity in testes, as well as the amount of oh8dG in testes DNA.
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