Role of the Basal Forebrain Neurons in Cortical Activation and Behavioural State Regulation

Symposium 388


Dr,. McCarley: Hope you are enjoying the meeting.  Great poster. I am a bit confused.   "This site-specific accumulation of AD during prolonged wakefulness suggests that the sleep-promoting effects of AD may be mediated by an AD inhibition of the BF cholinergic arousal system."   You also indicate that AD agonist infusion in the region promotes wakefulness.  To me this suggests that AD-receptor activation promotes wakefulness rather than the other way around.  Can you clarify how you arrive at this conclusion?

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