The second question is an interesting one. The effect of IL-1beta on the calcium channel is indirect through protein kinase C and via IL-1RI since IL-1 receptor antagonist completely blocks IL-1beta-induced modulation of the calcium channel currents. We have data that suggest the involvement of the L-type calcium channel. Carlos
On Fri Dec 4, grover wrote
>Dr. Plata-Salaman: I am glad to see your nice presentation and hope you enjoy the meeting. Two quick questions. First, what is the effect of antisense-IL-1R in the rats not given IL-1b? Second, is the effect of IL-1 directly on Ca-channel? Do you know which channel and at what site? That would be rather interesting.