Cytokines, Monoamines and Behavior

Illness, Cytokines, and Depression

Hymie Anisman

Raz -- I enjoyed reading your paper. I was amazed that you were able to get volunteers for your study of endotoxin effects on mood. I'm wondering what the physical effects were in these subjects. Was the dose sufficiently high to produce overt illness?

Also, would you know of ongoing studies assessing IL-1ra in humans, alone or as an adjunct, in treating depression?

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