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Brian McCarry and John Brennan, chemistry and biochemistry.
John Brennan and Brian McCarry
“Chemical biology is the theme of the $13-million Biomolecular
Interactions Initiative, a collaboration between the departments
of chemistry and biochemistry, that is providing new equipment,
lab space and research opportunities at the interface of life sciences
and chemistry.
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Two of the key players in the project are Drs. John Brennan
and Brian McCarry. Brennan, Canada Research Chair in Bioanalytical
Chemistry, develops new bioanalytical tools including protein
microarrays, bioaffinitiy chromatography columns and biosensors,
all of which are based on biomolecules that are entrapped
into inorganic silicate matrixes. The goal is to use these
devices to examine protein-protein and protein-small molecule
interactions in a high-throughput manner to accelerate the
discovery of drug leads and the identification of important
biomolecular interactions.
McCarry, holder of the Stephen A. Jarislowsky Chair in Environment
and Health, studies the transport and fate of environmental
contaminants using chemical and biochemical analyses, including
examining the genetic impacts of complex environmental mixtures
using DNA microarrays. Other work is directed at the development
of analytical methods for metabolomics, the complete profiling
of cell metabolites.
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