Invited Symposium: Arachidonic Acid Metabolites, Other Inflammatory Mediators and Intestinal Ion Transport
Poonyachoti, S. (Department of Veterinary PathoBiology, University of Minnesota, USA)
Green, B. (Department of Veterinary PathoBiology, University of Minnesota, USA)
Calvin, A. (Macalester College, USA)
Townsend, D. (Department of Veterinary PathoBiology, University of Minnesota, USA)
Active anion secretion protects the mucosa of the small intestine from infection by diluting and purging luminal antigens and enhancing the luminal extrusion of mucin, defensin peptides and other anti-infective substances. Histamine, substance P and other pro-inflammatory mediators, acting directly on enterocytes or indirectly through enteric neurons, evoke anion secretion in the small intestine. Several classes of analgesic/anesthetic drugs that are also subject to extensive human abuse, such as opioids, cannabinoids and cocaine, are known to decrease host resistance to systemic infections. However, their specific actions on intestinal host defense processes have not been fully elucidated. We will review evidence from the literature and our own research investigations arguing that these substances, through actions mediated largely through enteric neurons, can compromise the intestinal secretory defense mechanism.
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|Brown, D.R.; Poonyachoti, S.; Green, B.; Calvin, A.; Townsend, D.; (1998). Drugs of Abuse: Effects on Immunomodulation of Intestinal Ion Transport. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/rangacharipharm/brown0856/index.html|
|© 1998 Author(s) Hold Copyright|