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Pharmacology & Toxicology Poster Session






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Lack of Calmodulin Antagonism of Melatonin in T-Lymphocyte Activation

Woelfler, A. (Institute of General & Experimental Pathology, University of Graz, Austria)
Schauenstein, K. (Institute of General & Experimental Pathology, University of Graz, Austria)
Liebmann, P.M. (Institute of General & Experimental Pathology, University of Graz, Austria)

Contact Person: Peter M. Liebmann (peter.liebmann@kfunigraz.ac.at)


Abstract

Despite various reported effects of the pineal hormone melatonin on the immune system, its mechanism of action on immune cells is still unknown. Since melatonin has been suggested as a physiological antagonist to calmodulin in certain cell types, we investigated effects of melatonin on calmodulin-dependent IL-2 production and proliferation of activated T-lymphocytes. It was found, however, that, in contrast to the calmodulin antagonists trifluoperazine and W7, melatonin neither inhibited the IL-2 production of activated lymphoblastoid Jurkat T-cells nor decreased the mitogen response of peripheral blood mononuclear leukocytes. Preincubation of Jurkat cells with melatonin did not influence trifluoperazine effects on IL-2 production indicating that melatonin does not bind to the same sites of calmodulin as trifluoperazine, as has been postulated. In conclusion, these results did not give any evidence for a calmodulin antagonism of melatonin in T-lymphocyte activation. Thus, melatonin as a calmodulin antagonist appears not to be a universal phenomenon.

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Poster Number PAwoelfler0665
Keywords: melatonin, calmodulin, T-lymphocytes


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Woelfler, A.; Schauenstein, K.; Liebmann, P.M.; (1998). Lack of Calmodulin Antagonism of Melatonin in T-Lymphocyte Activation. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/pharmtox/woelfler0665/index.html
© 1998 Author(s) Hold Copyright