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Neuroscience Poster Session






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Enduring Vulnerability To Reinstatement Of Hemiplegia By Prazosin Or Clonidine After Recovery From Traumatic Brain Injury.

Stibick, D.L. (Department of Psychology, The University of New Mexico, USA)
Ortega, N.E. (Department of Psychology, The University of New Mexico, USA)
Feeney, D.M. (Departments of Psychology and Neurosciences, The University of New Mexico, USA)

Contact Person: Dennis M Feeney (feeney@unm.edu)


Abstract

A single dose of prazosin (PRAZ), an alpha-1 noradrenergic (NA) antagonist, or clonidine (CLON), an alpha-2 NA agonist, transiently reinstates hemiplegia measured by beam walk (BW) performance in recovered rats 30 days after sensorimotor cortex contusion by traumatic brain injury (TBI; Feeney & Westerberg, 1990, Can J Psychol, 44, 233-252.). Two experiments addressed the issue of endurance of hemiplegia reinstatement. The first investigated changes in reinstated BW deficit dose-response curves to PRAZ or the beta NA antagonist propranolol (PROP) repeated at 1, 3, & 6 mos. after TBI. Rats were equally vulnerable to transient reinstatement by PRAZ, but not PROP, at all times post-injury. The degree of reinstatement was dose-dependent and correlated to the severity of the initial deficit 24 hrs. post-TBI. The second experiment determined if tolerance to reinstatement of BW deficits developed after 3 injections of PRAZ or CLON given at 3 hr intervals. No tolerance was observed as both groups remained equally disabled over the 9 hour period of BW testing. Recovery of locomotor ability is a fragile state, perturbable by commonly prescribed drugs such as selective antagonists to alpha-1 NA receptors. Funded by UNM RAC grant, NIMH grant T34-MH19101.

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Poster Number PAstibick0798
Keywords: brain injury, trauma, noradrenalin, norepinephrine, recovery


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Stibick, D.L.; Ortega, N.E.; Feeney, D.M.; (1998). Enduring Vulnerability To Reinstatement Of Hemiplegia By Prazosin Or Clonidine After Recovery From Traumatic Brain Injury.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuroscience/stibick0798/index.html
© 1998 Author(s) Hold Copyright