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Neuropharmacology Poster Session






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Influence of endogenous histamine in 8-arm radial maze performance in rats

Chen, Z. (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan)
Sugimoto, Y. (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan)
Kamei, C. (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan)

Contact Person: Zhong Chen (d08304@pheasant.pharm.okayama-u.ac.jp)


Abstract

The effect of endogenous histamine on spatial cognition was investigated with 8-arm radial maze in rats. Intracerebroventricular (i.c.v.) injection of -fluorome thylhistidine (-FMH), a selective inhibitor of histidine decar- boxylase, resulted in spatial memory deficits, which are characterized by an increase in the number of total error (TE) and a decrease in the number of initial correct response (ICR). There is a high correlation between an increase in the number of TE and a decrease in histamine contents of the cortex and hippo- campus, which are known to partici pate in learning and memory. On the other hand, both histamine (50-100 ng, i.c.v.) and thioperamide (10* mg(microgrammer), i.c.v.) signi- ficantly ameliorated on memory deficit induced by -FMH. However, metoprine showed no significant effect on FMH-induced memory deficit. Pyrilamine and R-()-methylhistamine enhanced the memory deficit induced by -FMH, at doses which caused no appreciable effect when they were given alone. In contrast, no significant influence was observed with zolantidine in -FMH-induced memory deficit.

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Poster Number PAchen0322
Keywords: Histamine, -FMH, Radial maze, Thioperamide, Pyrilamine


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Chen, Z.; Sugimoto, Y.; Kamei, C.; (1998). Influence of endogenous histamine in 8-arm radial maze performance in rats. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/chen0322/index.html
© 1998 Author(s) Hold Copyright