***************
Invited Symposium






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
Board

INABIS '98 Home Page Your Session Symposia & Poster Sessions Plenary Sessions Exhibitors' Foyer Personal Itinerary New Search

Inward Hypertrophic Remodelling in Subcutaneous Small Arteries of Patients with Renovascular Hypertension, but Not with Primary Aldosteronism.


Contact Person: Damiano Rizzoni (Damiano.Rizzoni@schering-plough.it)


Results

No difference in age, gender, height, weight, serum cholesterol or triglycerides among the two groups was observed (data not shown). As expected, clinic blood pressure, plasma renin activity and plasma aldosterone were greater in RVH and PA than in NT (Table 1).

TABLE 1 Haemodynamic and humoral data 
                  NH        EH           PA               RVH
BP (mm Hg)   127/798/7  162/998/7  170/10313/9 ***  163/10416/12 ***
PRA (ng/ml/h)   1.11.2     1.21.1     0.200.31         6.236.17 *#
ALDO(pmol/ml)  0.300.28   0.410.30    1.530.60 ***#     1.220.72 **#
*=P<0.05, *** = P < 0.001 compared with NT, #=p<0.05 at least compared with EH. BP=blood pressure, ALDO= plasma aldosterone.

The morphological data in the different groups are summarized in Table 2.

TABLE 2 Morphological characteristics of the subcutaneous small resistance vessels.

	              NT         EH           PA            RVH
Normalized ID(mm)  30683      24568 *	    23071 *      22773 *
M/L (%)           5.81.5      8.62.0 ***  9.93.1 ***  12.05.0 ***#
MCSA (mm2)      140115302   160027991   175407218    219149433 *
CV (mm-3 *10-3)  2.050.32    2.280.44    2.420.64	 3.030.83 ***#
Cell length (mm)   7211       7720	     8421	   8722
NCSL (mm-1)       9.03.7     6.12.9	    9.33.7	  9.14.5
CL                4.51.1     4.11.4	    5.31.4	  4.71.4
*=P<0.05; ** = P < 0.01; *** = P < 0.001 compared with NT, #=p<0.05 at least compared with EH.ID= internal diameter, M/L=media to lumen ratio, MCSA=media cross-sectional area, CV=cell volume, NCSL=number of cells per segment length, CL=cell layers. Back to the top.

<= Materials & Methods RESULTS Discussion & Conclussions =>

| Discussion Board | Next Page | Your Symposium |
Rizzoni, D; Porteri, E; Piccoli, A; Castellano, M; Bettoni, G; Pasini, G; Mulvany, MJ; Agabiti, R.E; (1998). Inward Hypertrophic Remodelling in Subcutaneous Small Arteries of Patients with Renovascular Hypertension, but Not with Primary Aldosteronism.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/
© 1998 Author(s) Hold Copyright