***************
Immunology & Immunological Disorders Poster Session






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
Board

INABIS '98 Home Page Your Session Symposia & Poster Sessions Plenary Sessions Exhibitors' Foyer Personal Itinerary New Search

A Novel Anti-inflammatory Activity of Human Lysozyme: Modulation of Serum Complement Activation


Contact Person: Michael O. Ogundele (mogundel@yahoo.com)


Results

Lysozyme was added to the serum as a source of C in CH50 whole C assays. Concentrations ranging from 50 to 1500 microgrammes per millilitre were added, corresponding to expected physiological and pathological levels of lysozyme in the colostrum, mature or inflammed breast-milk, as well as other normal and inflammed body fluids. Lysozyme was found to inhibit the classical pathway of serum complement activity in a dose-dependent fashion within the concentration ranges tested (Fig. 1).

Figure 1 Inhibitory effect of human purified lysozyme on serum complement activities

At low concentrations corresponding to The inhibition physiological levels, the inhibitory effect of lysozyme was relatively minimal. The inhibition thereafter rises sharply with increasing concentrations, within pathological ranges.

Back to the top.


<= Materials & Methods RESULTS Discussion & Conclussions =>

| Discussion Board | Next Page | Your Poster Session |
Ogundele, M.O.; (1998). A Novel Anti-inflammatory Activity of Human Lysozyme: Modulation of Serum Complement Activation. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/immunology/ogundele0178/index.html
© 1998 Author(s) Hold Copyright