Arachidonic Acid Metabolites,
Other Inflammatory Mediators and Intestinal Ion Transport
Comment on paper by Dr. MacNaughton
Dr. MacNaughton: The COX results are interesting. Have you measured similar activities in the jejunum or ileum? How selective are the inhibitors, SC58125 and NS-398, do you have a Ki for COX-1 and COX-2? What is the conductance or change in conductance during the peak response when you add bradykinin, and arachidonic acid? Do you have a suggestion where the cell(s) that could constitutively synthesize COX-2 are located?
Mon Dec 14