Pharmacology & Toxicology Poster Session

Re: Poster 239

Jeremy Van Raamsdonk

For the most part we have been looking at diseases such as hemophilia where it isn't essential to target the protein to specific tissues and  as a result IP implantations are adequate.  

So far the only ions we have used to crosslink the alginate are Calcium, Barium and Iron(both 2+ and 3+). For various reasons the Calcium still seems to be the best when all factors are considered. If the other akaline earth metals(Mg, Be...) are in fact better crosslinkers than Calcium it would be important to ensure that they had no toxic side effects.
 
                               Jeremy Van Raamsdonk

On Mon Dec 7, Christopher M Tan wrote
-------------------------------------
>Dr. Van Raamsdonk,
>Interesting concepts- good luck with it! I was curious, how do you selectively target areas which may be isolated, ie., a certain tissue or organ which is deficient, for example for that elusive protein, have you conducted specific regional implants compared to IP injections?  Also, Barium falls into the alkaline earth metals- can you use other members of this group (ie., Mg, Ca, Be), to potentially avoid the toxicity associated with Barium?

>Regards,
>Christopher Tan

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